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Author
dc.contributor.author
Csernai, Márton 
Author
dc.contributor.author
Borbély, Sándor 
Author
dc.contributor.author
Kocsis, Kinga 
Author
dc.contributor.author
Burka, Dávid 
Author
dc.contributor.author
Fekete, Zoltán 
Author
dc.contributor.author
Balogh, Veronika 
Author
dc.contributor.author
Káli, Szabolcs 
Author
dc.contributor.author
Emri, Zsuzsa 
Author
dc.contributor.author
Barthó, Péter 
Availability Date
dc.date.accessioned
2020-09-21T20:47:14Z
Availability Date
dc.date.available
2020-09-21T20:47:14Z
Release
dc.date.issued
2019
uri
dc.identifier.uri
http://hdl.handle.net/10831/50645
Abstract
dc.description.abstract
Sleep spindle frequency positively, duration negatively correlates with brain temperature. Local heating of the thalamus produces similar effects in the heated area. Thalamic network model corroborates temperature dependence of sleep spindle frequency. Brain temperature shows spontaneous microfluctuations during both anesthesia and natural sleep. Larger fluctuations are associated with epochs of REM sleep. Smaller fluctuations correspond to the alteration of spindling and delta epochs of infra-slow oscillation.Every form of neural activity depends on temperature, yet its relationship to brain rhythms is poorly understood. In this work we examined how sleep spindles are influenced by changing brain temperatures and how brain temperature is influenced by sleep oscillations. We employed a novel thermoelectrode designed for measuring temperature while recording neural activity. We found that spindle frequency is positively correlated and duration negatively correlated with brain temperature. Local heating of the thalamus replicated the temperature dependence of spindle parameters in the heated area only, suggesting biophysical rather than global modulatory mechanisms, a finding also supported by a thalamic network model. Finally, we show that switches between oscillatory states also influence brain temperature on a shorter and smaller scale. Epochs of paradoxical sleep as well as the infra-slow oscillation were associated with brain temperature fluctuations below 0.2°C. Our results highlight that brain temperature is massively intertwined with sleep oscillations on various time scales.
Language
dc.language
Angol
Title
dc.title
Dynamics of sleep oscillations is coupled to brain temperature on multiple scales.
Type
dc.type
folyóiratcikk
Date Change
dc.date.updated
2020-09-03T11:47:28Z
Note
dc.description.note
Export Date: 6 March 2020 CODEN: JPHYA Correspondence Address: Barthó, P.; Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of SciencesHungary; email: bartho.peter@ttk.mta.hu
Scope
dc.format.page
4069-4086
Doi ID
dc.identifier.doi
10.1113/JP277664
Wos ID
dc.identifier.wos
000474732800001
ID Scopus
dc.identifier.scopus
85068711901
MTMT ID
dc.identifier.mtmt
30743670
Issue Number
dc.identifier.issue
15
abbreviated journal
dc.identifier.jabbrev
J PHYSIOL-LONDON
Journal
dc.identifier.jtitle
JOURNAL OF PHYSIOLOGY-LONDON
Volume Number
dc.identifier.volume
597
Release Date
dc.description.issuedate
2019
Pubmed ID
dc.identifier.pubmed
31197831
department of Author
dc.contributor.institution
Biomolekuláris Kémiai Intézet
department of Author
dc.contributor.institution
Gazdaságinformatika Doktori Iskola
department of Author
dc.contributor.institution
Thalamus Kutatócsoport
department of Author
dc.contributor.institution
Információs Technológiai Kar
department of Author
dc.contributor.institution
Anyagtudományok és Technológiák Doktori Iskola
department of Author
dc.contributor.institution
Matematikai Tanszék
department of Author
dc.contributor.institution
Állattani Tanszék
department of Author
dc.contributor.institution
MTA Kísérleti Orvostudományi Kutatóintézet
department of Author
dc.contributor.institution
MTA-TTK-NAP B Hálózat és Viselkedés Neurobiológiai kutatócsoport
department of Author
dc.contributor.institution
MTA-EK MFA-NAP B Implantálható Mikrorendszerek Kutatócsoport
Author institution
dc.contributor.department
MTA-TTK-NAP B Alvási Oszcillációk Kutatócsoport
Author institution
dc.contributor.department
Élettani és Neurobiológiai Tanszék
Author institution
dc.contributor.department
MTA-TTK-NAP B Alvási Oszcillációk Kutatócsoport
Author institution
dc.contributor.department
Roska Tamás Műszaki és Természettudományi Doktori Iskola
Author institution
dc.contributor.department
MTA-TTK-NAP B Hálózat és Viselkedés Neurobiológiai kutatócsoport
Author institution
dc.contributor.department
Matematikai Tanszék
Author institution
dc.contributor.department
Műszaki Fizikai és Anyagtudományi Intézet
Author institution
dc.contributor.department
Információs Technológiai és Bionikai Kar
Author institution
dc.contributor.department
MTA-TTK-NAP B Alvási Oszcillációk Kutatócsoport
Author institution
dc.contributor.department
MTA Kísérleti Orvostudományi Kutatóintézet


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Dynamics of sleep oscillations is coupled to brain temperature on multiple scales.
 

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