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Author
dc.contributor.author
Kutnyanszky, Vera 
Author
dc.contributor.author
Hargitai, Balazs 
Author
dc.contributor.author
Hotzi, Bernadette 
Author
dc.contributor.author
Kosztelnik, Monika 
Author
dc.contributor.author
Ortutay, Csaba 
Author
dc.contributor.author
Kovacs, Tibor 
Author
dc.contributor.author
Gyory, Eszter 
Author
dc.contributor.author
Borden, Kincso 
Author
dc.contributor.author
Princz, Andrea 
Author
dc.contributor.author
Tavernarakis, Nektarios 
Availability Date
dc.date.accessioned
2020-01-30T07:20:51Z
Availability Date
dc.date.available
2020-01-30T07:20:51Z
Release
dc.date.issued
2019
ID
dc.identifier
uri
dc.identifier.uri
http://hdl.handle.net/10831/46332
Abstract
dc.description.abstract
Females and males differ substantially in various neuronal functions in divergent, sexually dimorphic animal species, including humans. Despite its developmental, physiological and medical significance, understanding the molecular mechanisms by which sex-specific differences in the anatomy and operation of the nervous system are established remains a fundamental problem in biology. Here, we show that in Caenorhabditis elegans (nematodes), the global sex-determining factor TRA-1 regulates food leaving (mate searching), male mating and adaptation to odorants in a sex-specific manner by repressing the expression of goa-1 gene, which encodes the G alpha((i/o)) subunit of heterotrimeric G (guanine-nucleotide binding) proteins triggering physiological responses elicited by diverse neurotransmitters and sensory stimuli. Mutations in tra-1 and goa-1 decouple behavioural patterns from the number of X chromosomes. TRA-1 binds to a conserved binding site located in the goa-1 coding region, and downregulates goa-1 expression in hermaphrodites, particularly during embryogenesis when neuronal development largely occurs. These data suggest that the sex-determination machinery is an important modulator of heterotrimeric G protein-mediated signalling and thereby various neuronal functions in this organism and perhaps in other animal phyla.
Language
dc.language
Angol
Title
dc.title
Sex-specific regulation of neuronal functions in Caenorhabditis elegans: the sex-determining protein TRA-1 represses goa-1/G alpha((i/o))
Type
dc.type
folyóiratcikk
Date Change
dc.date.updated
2020-01-29T07:48:05Z
Note
dc.description.note
Funding Agency and Grant Number: Eotvos Lorand University (ELTE); Hungarian Scientific Research Funds OTKAOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [K109349, K132439]; MEDinPROT Protein Science Research Synergy Program; Advanced Investigator ERC grant "NeuronAge"; European Commission Marie Curie Actions Programme, Initial TrainingEuropean Union (EU); NIH Office of Research Infrastructure ProgramsUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P40 OD010440]; VEKOP [VEKOP-2.3.2-16-2017-00014] Funding text: Open access funding provided by Eotvos Lorand University (ELTE). This work was supported by the Hungarian Scientific Research Funds OTKA (K109349 and K132439) and MEDinPROT Protein Science Research Synergy Program to TV, and the Advanced Investigator ERC grant "NeuronAge" to NT. AP is supported by a European Commission Marie Curie Actions Programme, Initial Training. Some nematode strains were provided by the CGC (Caenorhabditis Genetics Center), which is founded by NIH Office of Research Infrastructure Programs (P40 OD010440). Funding was provided by VEKOP (Grant no. VEKOP-2.3.2-16-2017-00014).
Doi ID
dc.identifier.doi
10.1007/s00438-019-01625-0
Wos ID
dc.identifier.wos
000498986800001
ID Scopus
dc.identifier.scopus
85075591524
MTMT ID
dc.identifier.mtmt
30973023
Release Date
dc.description.issuedate
2019
Pubmed ID
dc.identifier.pubmed
31776761
department of Author
dc.contributor.institution
MTA-ELTE Genetikai Kutatócsoport
department of Author
dc.contributor.institution
Genetikai Tanszék
department of Author
dc.contributor.institution
Biológia Doktori Iskola
department of Author
dc.contributor.institution
Biológiai Intézet
Author institution
dc.contributor.department
Genetikai Tanszék
Author institution
dc.contributor.department
Genetikai Tanszék
Author institution
dc.contributor.department
Genetikai Tanszék
Author institution
dc.contributor.department
Genetikai Tanszék
Author institution
dc.contributor.department
Genetikai Tanszék


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Sex-specific regulation of neuronal functions in Caenorhabditis elegans: the sex-determining protein TRA-1 represses goa-1/G alpha((i/o))
 

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